Simon was the son of George and Lucinda (Irons) Weber.

From census records, his siblings were Lucy E Weber, Walter C Weber, Pearly M Weber, (Simon W Weber), Roy E Weber, Cora E Weber, Elmer G Weber, Earl W Weber, Ira R Weber, Hollie Weber, Otis Weber, George Weber, and Mable Weber.

He married Elizabeth Rapp on February 5, 1913 in Pontiac and became the father of Orville Weber, Ernest S. Weber, Evelyn Louise Weber Wilson, Melvin Dean Weber, Vernon Weber, Marie Elizabeth Weber Quigley, and Mildred Mae Weber Stangland.

Simon's sister, Cora Weber, married Otto Rapp who was his wife, Elizabeth Rapp's, older brother.

Simon died at age 53, just a six months after his wife, Elizabeth.
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1900 United States Federal Census
Home in 1900: Pontiac, Livingston, Illinois
Father: George Weber b. Illinois; Mother: Lucenday Weber b. Illinois
Household Members:
George Weber 43 (farmer) and Weber 34
Lucy E Weber 15
Water C Weber 12
Pearly M Weber 11
Simon W Weber 9
Roy E Weber 7
Cora E Weber 6
Elmer G Weber 4
Earl W Weber 1
Ira R Weber 4/12
Henry Hohn 22 (boarder)
Saddie Irons 22 (father's sister-in-law)
Verley Webster 23 (boarder)

1910 United States Federal Census
Home in 1910: Pontiac, Livingston, Illinois
Household Members:
George Weber 49 and Lucinda Weber 44
Walter Weber 23
Simon Weber 19
Roy Weber 17
Cora Weber 16
Elmer Weber 14
Earl Weber 11
Hollie Weber 10
Otis Weber 8
George Weber 4
Mable Weber 2

1920 United States Federal Census
Home in 1920: Eppards Point, Livingston, Illinois
Marital Status: Married to Elizabeth Rapp Weber
Home Owned: Rent
Able to Read: Yes; Able to Write: Yes
Household Members:
Simon W Weber 28 and Elizabeth Weber 26
Orville W Weber 6 4/12
Ernest S Weber 4 10/12
Evelyn L Weber 2 10/12

1930 United States Federal Census
Home in 1930: Eppards Point, Livingston, Illinois
Household Members:
Simon W Weber 39 (farmer) and Elizabeth Weber 37
Orville Weber 16
Ernest Weber 15
Evelyn Weber 13
Melvin Weber 8
Vernon Weber 5
Marie Weber 4 3/12
Mildred Weber 2 11/12